The Ursinus Weekly, February 13, 1933

Rev. R. A. Waite to speak in chapel Wed., Mar. 29 • Senior class to present unique musical comedy • Bear courtmen win 2 and lose 1; close inter-dormitory contests • Grizzly grapplers will meet F. and M. and Gettysburg • Phila. alumni to hold annual dinner Feb. 24 • Council on student activities sponsors dance • Y.M. and Y.W.C.A. secure week of prayer speaker • Movies on scientific topics shown in science hall • Men\u27s debating teams hold trial debates • Chapel speaker secured for Washington\u27s birthday • Religion and art discussed at joint YM & YW meeting • Phoenixville alumnae bow to coed basketball team • New staff members • Senior ball committee • Fraternity pledges • Glee Club renders concert at Phoenixville high school • Jr. advisory committee procures several speakers • Freshmen debating team selected for coming season • Brotherhood of St. Paul to hold series of discussions • World affairs reviewed at int. relations meeting • Prof. Fenwick to speak at H. S. group meeting • Y.M.C.A. chorus at Trappe • Frosh quintet drop game to Drexel frosh • Women\u27s student council makes plans for Color Dayhttps://digitalcommons.ursinus.edu/weekly/2045/thumbnail.jp

Strategy for encoding and comparison of gene expression signatures

EXALT (EXpression signature AnaLysis Tool) enables comparisons of microarray data across experimental platforms and different laboratories

The Ursinus Weekly, September 19, 1932

Academic exercises open sixty-third year at Ursinus college • Y.M.-Y.W.C.A. stage annual reception for frosh • Bears show promise in scrimmage; favorable prospects for season • Student governments take part in orientation program • Cross country candidates will report today • Band to organize for football season • New football programs will appear soon • Men\u27s student council holds initial meeting • Sophs give freshmen a rigid inspection • Wanted: cheerleaders • Haverford game cancelled • Mr. Willauer married • Student council sponsors reception for freshmen • College Sunday school plans for coming year • Y.M.C.A. all set for year\u27s activities • Many campus improvements made during summer • Soccer begins its second year at Ursinus • Freshman discussions are sponsored for girls • New physics course offered to freshmen • Y.W. makes plan for coming year at breakfast • Frosh gridders practice • Frosh-soph tug of war • Private music lessons • Vespers • Library secures collection of new fiction bookshttps://digitalcommons.ursinus.edu/weekly/2028/thumbnail.jp

The Ursinus Weekly, April 18, 1932

Spring convention of I.N.A. held at Haverford College • Student party attends opera Aida, April 14 • Inter-class track meet will be featured April 21 • Bears drop close game to Drexel Dragons, 8-6 • Tal Henry will play for junior promenade • Sophs win track meet • Inter-class track trophy • Physical Education group features novel demonstration • Interesting Ruby changes • Johnson compiles survey of Ursinus athletic system • Dr. J. Boyd Edwards will speak • Oratorio rehearsals begun • Junior play, April 30 • Questionnaire ends April 20 • The Paisley prizes • Men\u27s negative debating team defeats Villanova • Co-ed debaters lose; tie Penn State contests • Girl problems discussed by Mrs. Holzopple at YW • Editorial: Depression vs. college students • Lodge receives honor • Y officers chosen • WSGA officers begin with annual banquet • Professor Bone speaks on capitalism at Y meeting • Poetry is theme of English Club meeting Monday night • YM will install officers • Tennis tournament delayed • Cooperation for May Day event urged by Mrs. Ogden • Dr. Roxby to address clubhttps://digitalcommons.ursinus.edu/weekly/2083/thumbnail.jp

The Ursinus Weekly, May 23, 1932

Results of Carnegies prove very interesting • Varsity stickmen score first victory of season • Dr. MacFarland addresses students at chapel service • Men\u27s student council elected for next year • Lehigh Valley alumni hold annual meeting • Frosh keep clean slate • Tau Kappa Alpha initiates • Dr. and Mrs. George Leslie Omwake hosts at annual reception • Alumni athletic club meeting Saturday, June 4 • Tracksters place third in conference meet • Women\u27s Club board meets • Race relations discussion held with Lincoln University men • Curtain Club chooses • College is host to Hi-Y and Tri-Hi-Y conference • Editorial comment: Chapel twice a week • Handbook staff completed • Mathematics group doggie roast • Women\u27s tennis team loses to Swarthmore, 3-2 • Y hikes to Lost Lake • Professor J. H. Brownback heads council on social activities • Freshmen essay contest • International Relations Club wiener roast • Men\u27s Debating Club elects • Women\u27s Debating election • Music Club chooses officers • Modern Language group elects • English group chooseshttps://digitalcommons.ursinus.edu/weekly/2088/thumbnail.jp

The Ursinus Weekly, March 20, 1933

Senior ball Friday night will feature Dell Lampe • Student\u27s secret desires bared by Weekly snoopers • Connie Mack to speak at Varsity Club banquet • University of Maine to send debaters to Ursinus • Brodbeck takes laurels in wrestling tournaments • Rev. R. A. Waite to speak at chapel exercises Mar. 29 • Favorable prospects for winning baseball team • Coach McAvoy to succeed Dr. Rubin as track mentor • Pres. Omwake announces series of important events • Senior play Topsy and Eva Thursday and Saturday nights • Paris to grapple in nationals at Lehigh • Sophomore men elect student council members • Chase elected vice-pres. of basketball league • Varsity basketball team swamps alumnae, 47-2 • Organ recital rendered at vespers Sunday evening • Prof. Michael entertains the men\u27s faculty club • Prof. Boswell to speak • Rev. Wilhelm addresses weekly YM meeting • Men\u27s affirmative debating team completes road trip • Mixed debating teams clash with Drexel institute • Women debaters lose to Lebanon Valley • Y conference will be of campus-wide interest • Girl reserve code discussed at YWCA meeting • Large number report for first oratorio practice • Chemical society makes plans for coming meeting • Women\u27s student council renovates recreation hall • Modern essayists discussed at English Club meeting • Day study and South Hall lead in inter-dorm leaguehttps://digitalcommons.ursinus.edu/weekly/2050/thumbnail.jp

The Ursinus Weekly, October 31, 1932

Artist-students present pleasing concert, Oct. 27 • Eminent German actor to appear on Ursinus campus • Ursinus bears outplay Gettysburg Bullets but lose tight game, 7-2 • Banquet brings Fathers\u27 Day program to close • Straw ballot results • Wrestling candidates report to coach Carleton • Plans for organization made by college chemists • Presidential poll shows a landslide for Hoover • Republican party stages political rally in gym • Soccer team scores first intercollegiate victory • Curtain Club to present Schaff play, December 2 • Glee Club schedules two concerts next month • Ursinus represented at AAUW conference • Memorial services held for Prof. Harry Bretz • Alumni tea • Senior class plans to have Halloween hop • World politics discussed by International Relations Club • Y.W. discusses socialism at third political rally • Men\u27s Debating Club holds initial meeting • Orchestra selected for pan-Hellenic ball • Girl\u27s Glee Club meets; plans for coming year • Rev. Faye of Norristown addresses YMCA meeting • Dr. J. B. Price speaks at enthusiastic pep meeting • English Club meets at Glenwood Hall • College Sunday school holds Halloween party • Mathematics group gathers in science building • Varsity hockeyists and second team practicehttps://digitalcommons.ursinus.edu/weekly/2034/thumbnail.jp

The Ursinus Weekly, December 5, 1932

Black flamingo offered by Curtain Club as annual Schaff production • Pan-Hellenic climaxes a brilliant week-end • Football summary reveals fairly successful season • Lettermen elect Tropp to captain 1933 grid team • Dr. Mackay will address YMCA conference • Bear basketball team to open season at Princeton • Football conferences are scheduled for December • Professor J. H. Brownback addresses pre-med. society • Glee Club renders concert at Norristown hospital • Hershey Chocolate Company presents talking pictures • Prof. Sheeder speaks at YWCA meeting • Y.M. and Y.W. select possible chapel speakers • Tryouts to be held by women\u27s Debating Club • Sophomores down yearlings in annual gridiron battle, 6-0 • Hockey team elects captain and managers • Sophomores win annual inter-class hockey game • Eighteen football men recommended for letters • Plans already made for Christmas pageant • Some historical lines from The Black flamingo • Ursinus mentioned for Tournament of Roseshttps://digitalcommons.ursinus.edu/weekly/2039/thumbnail.jp

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels

Propranolol is a widely used, non-selective β-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for β-adrenergic receptor inhibition, propranolol also exhibits anti-arrhythmic (“membrane stabilizing”) effects that are not fully explained by β-blockade. Previous in vitro studies suggested that propranolol may have local anesthetic effects. We directly tested the effects of propranolol on heterologously expressed recombinant human cardiac (NaV1.5) and brain (NaV1.1, NaV1.2, NaV1.3) sodium channels using whole-cell patch-clamp recording. We found that block was not stereospecific as we observed approximately equal IC50 values for tonic and use-dependent block by R-(+) and S-(−) propranolol (tonic block: R: 21.4 μM vs S: 23.6 μM; use-dependent block: R: 2.7 μM vs S: 2.6 μM). Metoprolol and nadolol did not block NaV1.5 indicating that sodium channel block is not a class effect of β-blockers. The biophysical effects of R-(+)-propranolol on NaV1.5 and NaV1.1 resembled that of the prototypical local anesthetic lidocaine including the requirement for a critical phenylalanine residue (F1760 in NaV1.5) in the domain 4 S6 segment. Finally, we observed that brain sodium channels exhibited less sensitivity to R-(+)-propranolol than NaV1.5 channels. Our findings establish sodium channels as targets for propranolol and may help explain some beneficial effects of the drug in treating cardiac arrhythmias, and may explain certain adverse central nervous system effects